EIF2AK1 Antibody
Produktgrößen
100 ug
£496,00
OAAF03655-100UG
Über dieses Produkt
- SKU:
- OAAF03655
- Zusätzliche Namen:
- eukaryotic translation initiation factor 2-alpha kinase 1;HCR;heme regulated initiation factor 2 alpha kinase;heme sensitive initiation factor 2a kinase;heme-controlled repressor;heme-regulated eukaryotic initiation factor eIF-2-alpha kinase;heme-regulated inhibitor;heme-regulated repressor;hemin-sensitive initiation factor 2-alpha kinase;hHRI;HRI;LEMSPAD.
- Klonalität:
- Polyclonal
- Weitere Details:
- Inhibits protein synthesis at the translation initiation level; in response to various stress conditions; including oxidative stress; heme deficiency; osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51'; thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity; allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity; plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs); controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly; in hepatocytes; involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).
- Gendetails:
- eukaryotic translation initiation factor 2 alpha kinase 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human EIF2AK1.
- Molekulargewicht:
- 71 kDa
- Proteindetails:
- Eukaryotic translation initiation factor 2-alpha kinase 1
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php