AZI1 Antibody
Produktgrößen
100 ug
£496,00
OAAF03167-100UG
Über dieses Produkt
- SKU:
- OAAF03167
- Zusätzliche Namen:
- 5-azacytidine induced 1;5-azacytidine-induced protein 1;AZ1;AZI1;centrosomal protein 131 kDa;centrosomal protein 131kDa;centrosomal protein of 131 kDa;pre-acrosome localization protein 1;ZA1.
- Klonalität:
- Polyclonal
- Weitere Details:
- Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613; PubMed:24185901). In proliferating cells; MIB1-mediated ubiquitination induces its sequestration within centriolar satellites; precluding untimely cilia formation initiation (PubMed:24121310). In contrast; during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis; its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310; PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking; which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915; PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152; WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).
- Gendetails:
- centrosomal protein 131
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human AZI1.
- Molekulargewicht:
- 122 kDa
- Proteindetails:
- Centrosomal protein of 131 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php