CDK5RAP2 Antibody
Produktgrößen
100 ug
£496,00
OAAF02895-100UG
Über dieses Produkt
- SKU:
- OAAF02895
- Zusätzliche Namen:
- C48;CDK5 activator-binding protein C48;CDK5 regulatory subunit-associated protein 2;centrosomal protein 215 kDa;Centrosome-associated protein 215;centrosomin;Cep215;MCPH3.
- Klonalität:
- Polyclonal
- Weitere Details:
- Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1; may promote microtubule polymerization; bundle formation; growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE; MAPRE1 and AKAP9; contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity).
- Gendetails:
- CDK5 regulatory subunit associated protein 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CDK5RAP2.
- Molekulargewicht:
- 215 kDa
- Proteindetails:
- CDK5 regulatory subunit-associated protein 2
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php