EIF2AK3 Antibody
Produktgrößen
100 ug
£496,00
OAAF02710-100UG
Über dieses Produkt
- SKU:
- OAAF02710
- Zusätzliche Namen:
- eukaryotic translation initiation factor 2-alpha kinase 3;pancreatic EIF2-alpha kinase;PEK;PERK;PRKR-like endoplasmic reticulum kinase;truncated eukaryotic translation initiation factor 2 alpha kinase 3;WRS.
- Klonalität:
- Polyclonal
- Weitere Details:
- Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor; leading to a reduced overall utilization of amino acids; or to a translation initiation activator of specific mRNAs; such as the transcriptional activator ATF4; and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
- Gendetails:
- eukaryotic translation initiation factor 2 alpha kinase 3
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human E2AK3.
- Molekulargewicht:
- 125 kDa
- Proteindetails:
- Eukaryotic translation initiation factor 2-alpha kinase 3
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php