BATF Antibody
Produktgrößen
100 ug
£496,00
OAAF02470-100UG
Über dieses Produkt
- SKU:
- OAAF02470
- Zusätzliche Namen:
- activating transcription factor B;basic leucine zipper transcription factor; ATF-like;basic leucine zipper transcriptional factor ATF-like;B-ATF;BATF1;B-cell-activating transcription factor;SFA2;SFA-2;SF-HT-activated gene 2 protein.
- Klonalität:
- Polyclonal
- Weitere Details:
- AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17); follicular T-helper cells (TfH); CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells; leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'); an immune-specific regulatory element; followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells; involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection; can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage; part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3; leading to differentiation of HSCs; thereby restricting self-renewal of HSCs (By similarity).
- Gendetails:
- basic leucine zipper ATF-like transcription factor
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human BATF.
- Molekulargewicht:
- 14 kDa
- Proteindetails:
- Basic leucine zipper transcriptional factor ATF-like
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php