CBFA2T3 Antibody
Produktgrößen
100 ug
£496,00
OAAF02383-100UG
Über dieses Produkt
- SKU:
- OAAF02383
- Zusätzliche Namen:
- CBFA2/RUNX1 translocation partner 3;core-binding factor; runt domain; alpha subunit 2; translocated to; 3;ETO2;MTG16;MTG8-related gene 2;MTG8-related protein 2;MTGR2;myeloid translocation gene 8 and 16b;myeloid translocation gene on chromosome 16 protein;protein CBFA2T3;RUNX1T3;zinc finger MYND domain-containing protein 4;ZMYND4.
- Klonalität:
- Polyclonal
- Weitere Details:
- Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562; PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3; PFKFB4; PDK1; PFKP; LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896; PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).
- Gendetails:
- CBFA2/RUNX1 partner transcriptional co-repressor 3
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MTG16.
- Molekulargewicht:
- 71 kDa
- Proteindetails:
- Protein CBFA2T3
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php