GLI3 Antibody
Produktgrößen
100 ug
£496,00
OAAF02129-100UG
Über dieses Produkt
- SKU:
- OAAF02129
- Zusätzliche Namen:
- ACLS;GCPS;GLI3 form of 190 kDa;GLI3 full-length protein;GLI3-190;GLI3FL;GLI-Kruppel family member GLI3;glioma-associated oncogene family zinc finger 3;oncogene GLI3;PAPA;PAP-A;PAPA1;PAPB;PHS;PPDIV;transcriptional activator GLI3;zinc finger protein GLI3.
- Klonalität:
- Polyclonal
- Weitere Details:
- Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway; and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation; acts as an activator (GLI3A) while GLI3R; its C-terminally truncated form; acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R; rather than the repressor gradient itself or the activator/repressor ratio gradient; specifies limb digit number and identity. In concert with TRPS1; plays a role in regulating the size of the zone of distal chondrocytes; in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
- Gendetails:
- GLI family zinc finger 3
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human GLI-3.
- Molekulargewicht:
- 13 kDa
- Proteindetails:
- Transcriptional activator GLI3
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php