BUB1B Antibody
Produktgrößen
100 ug
£496,00
OAAF02041-100UG
Über dieses Produkt
- SKU:
- OAAF02041
- Zusätzliche Namen:
- Bub1A;BUB1B; mitotic checkpoint serine/threonine kinase;BUB1beta;BUBR1;budding uninhibited by benzimidazoles 1 homolog beta;hBUBR1;MAD3/BUB1-related protein kinase;MAD3L;mitotic checkpoint kinase MAD3L;mitotic checkpoint serine/threonine-protein kinase BUB1 beta;MVA1;Protein SSK1;SSK1.
- Klonalität:
- Polyclonal
- Weitere Details:
- Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C; independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
- Gendetails:
- BUB1 mitotic checkpoint serine/threonine kinase B
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human BUB1B.
- Molekulargewicht:
- 119 kDa
- Proteindetails:
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php