GABBR1 Antibody
Produktgrößen
100 ug
£496,00
OAAF01800-100UG
Über dieses Produkt
- SKU:
- OAAF01800
- Zusätzliche Namen:
- GABA-B receptor; R1 subunit;GABABR1;GABBR1-3;gamma-aminobutyric acid (GABA) B receptor; 1;gamma-aminobutyric acid type B receptor subunit 1;GB1;GPRC3A;seven transmembrane helix receptor.
- Klonalität:
- Polyclonal
- Weitere Details:
- Component of a heterodimeric G-protein coupled receptor for GABA; formed by GABBR1 and GABBR2 (PubMed:9872316; PubMed:9872744; PubMed:15617512; PubMed:18165688; PubMed:22660477; PubMed:24305054). Within the heterodimeric GABA receptor; only GABBR1 seems to bind agonists; while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors; such as adenylate cyclase (PubMed:10906333; PubMed:10773016; PubMed:10075644; PubMed:9872744; PubMed:24305054). Signaling inhibits adenylate cyclase; stimulates phospholipase A2; activates potassium channels; inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels; whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003; PubMed:9872316; PubMed:10075644; PubMed:9872744; PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation; slow wave sleep; muscle relaxation and antinociception (Probable). Activated by (-)-baclofen; cgp27492 and blocked by phaclofen (PubMed:9844003; PubMed:9872316; PubMed:24305054).
- Gendetails:
- gamma-aminobutyric acid type B receptor subunit 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human GABA-B Receptor.
- Molekulargewicht:
- 108 kDa
- Proteindetails:
- Gamma-aminobutyric acid type B receptor subunit 1
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php