CUL2 Antibody
Produktgrößen
100 ug
£496,00
OAAF01766-100UG
Über dieses Produkt
- SKU:
- OAAF01766
- Zusätzliche Namen:
- CUL-2;cullin-2;testis secretory sperm-binding protein Li 238E.
- Klonalität:
- Polyclonal
- Weitere Details:
- Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes; which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
- Gendetails:
- cullin 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Cullin 2.
- Molekulargewicht:
- 86 kDa
- Proteindetails:
- Cullin-2
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php