BMX Antibody
Produktgrößen
100 ug
£496,00
OAAF00942-100UG
Über dieses Produkt
- SKU:
- OAAF00942
- Zusätzliche Namen:
- bone marrow tyrosine kinase gene in chromosome X protein;BTK-like on X chromosome;cytoplasmic tyrosine-protein kinase BMX;epithelial and endothelial tyrosine kinase;ETK;Etk/Bmx cytosolic tyrosine kinase;NTK38;NTK38 tyrosine kinase;PSCTK2;PSCTK3.
- Klonalität:
- Polyclonal
- Weitere Details:
- Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization; cell migration; cell proliferation and survival; cell adhesion; and apoptosis. Participates in signal transduction stimulated by growth factor receptors; cytokine receptors; G-protein coupled receptors; antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1; a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis; and implicated in the signaling of TEK and FLT1 receptors; 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3; a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems; salivary epithelial cells; brain endothelial cells; and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
- Gendetails:
- BMX non-receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human ETK.
- Molekulargewicht:
- 78 kDa
- Proteindetails:
- Cytoplasmic tyrosine-protein kinase BMX
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php