AhR Antibody
Produktgrößen
100 ug
£496,00
OAAF00925-100UG
Über dieses Produkt
- SKU:
- OAAF00925
- Zusätzliche Namen:
- ah receptor;AHH;AHHR;ahR repressor;AH-receptor;aromatic hydrocarbon receptor;aryl hydrocarbon hydroxylase regulator;aryl hydrocarbon receptor;aryl hydrocarbon receptor repressor;bHLHe76;bHLHe77;class E basic helix-loop-helix protein 76;class E basic helix-loop-helix protein 77;dioxin receptor repressor;RP85.
- Klonalität:
- Polyclonal
- Weitere Details:
- Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).|Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2; HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
- Gendetails:
- aryl hydrocarbon receptor|aryl-hydrocarbon receptor repressor
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human AhR.
- Isotyp:
- IgG
- Molekulargewicht:
- 96 kDa
- Proteindetails:
- Aryl hydrocarbon receptor|Aryl hydrocarbon receptor repressor
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php