CCDC88A Antibody
Produktgrößen
100 ug
£496,00
OAAF00550-100UG
Über dieses Produkt
- SKU:
- OAAF00550
- Zusätzliche Namen:
- Akt phosphorylation enhancer;AKT-phosphorylation enhancer;APE;Coiled-coil domain-containing protein 88A;g alpha-interacting vesicle-associated protein;Girders of actin filament;girders of actin filaments;girdin;GIV;GRDN;HkRP1;Hook-related protein 1;KIAA1212;PEHO;PEHOL.
- Klonalität:
- Polyclonal
- Weitere Details:
- Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis; including correct neuron positioning; dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB; but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR; and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382).
- Gendetails:
- coiled-coil domain containing 88A
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Girdin around the phosphorylation site of Ser1417.
- Molekulargewicht:
- 216 kDa
- Proteindetails:
- Girdin
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php