ATR Antibody
Produktgrößen
100 ug
£496,00
OAAF00519-100UG
Über dieses Produkt
- SKU:
- OAAF00519
- Zusätzliche Namen:
- ataxia telangiectasia and Rad3-related protein;FCTCS;FRAP-related protein 1;FRAP-related protein-1;FRP1;MEC1;MEC1; mitosis entry checkpoint 1; homolog;SCKL;SCKL1;serine/threonine-protein kinase ATR.
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR); ultraviolet light (UV); or DNA replication stalling; thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1; CHEK1; MCM2; RAD17; RPA2; SMC1 and p53/TP53; which collectively inhibit DNA replication and mitosis and promote DNA repair; recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage; thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
- Gendetails:
- ATR serine/threonine kinase
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human ATR around the phosphorylation site of Ser428.
- Isotyp:
- IgG
- Molekulargewicht:
- 301 kDa
- Proteindetails:
- Serine/threonine-protein kinase ATR
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php