ERBB2 Antibody
Produktgrößen
100 ug
£496,00
OAAF00332-100UG
Über dieses Produkt
- SKU:
- OAAF00332
- Zusätzliche Namen:
- CD340;c-erb B2/neu protein;HER2;HER-2;HER-2/neu;herstatin;human epidermal growth factor receptor 2;metastatic lymph node gene 19 protein;MLN 19;NEU;neuro/glioblastoma derived oncogene homolog;neuroblastoma/glioblastoma derived oncogene homolog;NGL;p185erbB2;proto-oncogene c-ErbB-2;proto-oncogene Neu;receptor tyrosine-protein kinase erbB-2;TKR1;tyrosine kinase-type cell surface receptor HER2;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2;v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog;VSCN2.
- Klonalität:
- Polyclonal
- Weitere Details:
- Protein tyrosine kinase that is part of several cell surface receptor complexes; but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex; although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation; the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2; allowing its association with the cell membrane. In turn; membrane-bound APC allows the localization of MACF1 to the cell membrane; which is required for microtubule capture and stabilization.
- Gendetails:
- erb-b2 receptor tyrosine kinase 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human HER2 around the phosphorylation site of Tyr1248.
- Molekulargewicht:
- 137 kDa
- Proteindetails:
- Receptor tyrosine-protein kinase erbB-2
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php