AURB/C Antibody
Produktgrößen
100 ug
£496,00
OAAF00261-100UG
Über dieses Produkt
- SKU:
- OAAF00261
- Zusätzliche Namen:
- AIE2;AIK2;AIK3;AIM1;AIM-1;ARK2;ARK-2;ARK3;ARK-3;AurB;AurC;aurkb-sv1;aurkb-sv2;Aurora 1;aurora 3;aurora- and Ipl1-like midbody-associated protein 1;aurora kinase B;aurora kinase B-Sv1;aurora kinase B-Sv2;aurora kinase C;aurora/IPL1/EG2 protein 2;aurora/IPL1-related kinase 2;aurora/IPL1-related kinase 3;aurora-1;aurora-B;aurora-C;aurora-related kinase 2;aurora-related kinase 3;epididymis secretory protein Li 90;HEL-S-90;IPL1;PPP1R48;protein phosphatase 1; regulatory subunit 48;serine/threonine kinase 12;serine/threonine kinase 13 (aurora/IPL1-like);serine/threonine-protein kinase 12;serine/threonine-protein kinase 13;serine/threonine-protein kinase 5;serine/threonine-protein kinase aurora-B;serine/threonine-protein kinase aurora-C;SPGF5;STK-1;STK12;STK13;STK5.
- Klonalität:
- Polyclonal
- Weitere Details:
- Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC); a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint; a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C; leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861; PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin; CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA; DES/desmin; GPAF; KIF2C; NSUN2; RACGAP1; SEPT1; VIM/vimentin; HASPIN; and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process; whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph; respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells; inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.|Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC); a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB; AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1; another protein involved in cell division; at 'Ser-228'.
- Gendetails:
- aurora kinase B|aurora kinase C
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human AurB/C around the phosphorylation site of Thr236/202.
- Molekulargewicht:
- 39 kDa
- Proteindetails:
- Aurora kinase B|Aurora kinase C
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho-peptide. The antibody against non-phosphopeptide was removed by chromatography using corresponding non-phospho
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php