CENPA Antibody
Produktgrößen
100 ug
£496,00
OAAF00181-100UG
Über dieses Produkt
- SKU:
- OAAF00181
- Zusätzliche Namen:
- CenH3;CENP-A;centromere autoantigen A;Centromere protein A;centromere protein A; 17kDa;centromere-specific histone;histone H3-like centromeric protein A.
- Klonalität:
- Polyclonal
- Weitere Details:
- Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047; PubMed:9024683; PubMed:11756469; PubMed:14667408; PubMed:15702419; PubMed:15475964; PubMed:15282608; PubMed:17651496; PubMed:19114591; PubMed:27499292; PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292; PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964; PubMed:15282608; PubMed:26878239; PubMed:20739937; PubMed:21478274). Required for recruitment and assembly of kinetochore proteins; and as a consequence required for progress through mitosis; chromosome segregation and cytokinesis (PubMed:11756469; PubMed:14667408; PubMed:18072184; PubMed:23818633; PubMed:25556658; PubMed:27499292).
- Gendetails:
- centromere protein A
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Centromeric Protein A around the phosphorylation site of Ser7.
- Molekulargewicht:
- 15 kDa
- Proteindetails:
- Histone H3-like centromeric protein A
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php