ELK1 Antibody
Produktgrößen
0.1 mg
£500,00
OAAD00439-0.1MG
Über dieses Produkt
- SKU:
- OAAD00439
- Zusätzliche Namen:
- BEC2; ELK1; Kv12.3
- translate.label.attr.clone:
- 7E10D5; 7E10E8
- Klonalität:
- Monoclonal
- Weitere Details:
- The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily; which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus; It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase; the kinetics of Elk1phosphorylation and activa- tion correlate with MAP kinase activity; and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.
- Host:
- Mouse
- Isotyp:
- IgG1
- Proteindetails:
- Potassium voltage-gated channel subfamily H member 4
- Versandbedingungen:
- Blue Ice
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php