CDH1 Antibody
Produktgrößen
0.1ml
£522,00
OAAD00383-0.1ML
Über dieses Produkt
- SKU:
- OAAD00383
- Zusätzliche Namen:
- UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324
- translate.label.attr.clone:
- 7H12
- Klonalität:
- Monoclonal
- Weitere Details:
- E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells.
There; it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule; E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes; leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive; poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus; loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. - Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of human CDH1 expressed in E. Coli.
- Isotyp:
- IgG1
- Molekulargewicht:
- 135kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C; for long term storage; store at -20C.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php