EPCAM Antibody
Produktgrößen
0.1ml
£522,00
OAAD00361-0.1ML
Über dieses Produkt
- SKU:
- OAAD00361
- Zusätzliche Namen:
- ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
- Klonalität:
- Monoclonal
- Weitere Details:
- This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.ABCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups; and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM; many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues; with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells.
EpCAM expression has been reported to be a possible marker of early malignancy; with expression being increased in tumour cells; and de novo expression being seen in dysplastic squamous epithelium.BIOLEGEND:This cell surface; glycosyl;ated 40kD protein is highly expressed in the bone marrow; colon; lung; and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. - Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of human EPCAM expressed in E. Coli.
- Isotyp:
- IgG1
- Molekulargewicht:
- 35kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C; for long term storage; store at -20C.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php