ATP2C1 Antibody
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0.1ml
£522,00
OAAD00345-0.1ML
Über dieses Produkt
- SKU:
- OAAD00345
- Zusätzliche Namen:
- HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A
- translate.label.attr.clone:
- 4G12
- Klonalität:
- Monoclonal
- Weitere Details:
- ATP2C1; also known as PMR1; it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue; ATP2C1 (also designated SPLA in rat); also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members; such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants; which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease; which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
- Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of ATP2C1 expressed in E. Coli.
- Isotyp:
- IgG1
- Molekulargewicht:
- 100kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C; for long term storage; store at -20C.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php