CK17 Antibody
Produktgrößen
0.1ml
£522,00
OAAD00314-0.1ML
Über dieses Produkt
- SKU:
- OAAD00314
- Zusätzliche Namen:
- PC; K17; PC2; 39.1; CK-17; PCHC1
- translate.label.attr.clone:
- 3B12
- Klonalität:
- Monoclonal
- Weitere Details:
- CK17; also known as KRT17; it is the type I intermediate filament chain keratin 17. It is found in nail beds; hair follicles; sebaceous glands; and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages; specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis; with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles; in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
- Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of CK17 expressed in E. Coli.
- Isotyp:
- IgG2b
- Molekulargewicht:
- 49kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C; for long term storage; store at -20C.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php