FGFR4 Antibody
Produktgrößen
0.1ml
£522,00
OAAD00300-0.1ML
Über dieses Produkt
- SKU:
- OAAD00300
- Zusätzliche Namen:
- TKF; JTK2; CD334
- translate.label.attr.clone:
- 7H1
- Klonalität:
- Monoclonal
- Weitere Details:
- FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family; where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region; composed of three immunoglobulin-like domains; a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors; setting in motion a cascade of downstream signals; ultimately influencing mitogenesis and differentiation. The genomic organization of this gene; compared to members 1-3; encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed; there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms; as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and; although its specific function is unknown; it is overexpressed in gynecological tumor samples; suggesting a role in breast and ovarian tumorigenesis.
- Host:
- Mouse
- Immunogen:
- Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.
- Isotyp:
- IgG1
- Molekulargewicht:
- 87.9kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C; for long term storage; store at -20C.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php