Fgr Antibody - middle region
Produktgrößen
400ul
£597,00
OAAB18977-400UL
Über dieses Produkt
- SKU:
- OAAB18977
- Zusätzliche Namen:
- Al; Ali18; Mhdaa; Mhdaali18
- Klonalität:
- Polyclonal
- Weitere Details:
- Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses; including neutrophil; monocyte; macrophage and mast cell functions; cytoskeleton remodeling in response to extracellular stimuli; phagocytosis; cell adhesion and migration. Promotes mast cell degranulation; release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins; such as MS4A2/FCER1B; FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2; and regulates actin cytoskeleton reorganization; cell spreading and adhesion. Depending on the context; activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling; phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling; normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673 and PubMed:9687507). Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells; leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG; and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL; CTTN; PIK3R1; PTK2/FAK1; PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK; but not unphosphorylated HCLS1.
- Host:
- Rabbit
- Immunogen:
- This Mouse Fgr antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 232-265 amino acids from the Central region of Mouse Fgr.
- Isotyp:
- Rabbit Ig
- Molekulargewicht:
- 59 kDa
- Aufreinigung:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php