CSF1R Antibody
Produktgrößen
400ul
£630,00
OAAB18690-400UL
Über dieses Produkt
- SKU:
- OAAB18690
- Zusätzliche Namen:
- FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; BANDDOS; M-CSF-R
- translate.label.attr.clone:
- 1486CT328.53.37
- Klonalität:
- Monoclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival; proliferation and differentiation of hematopoietic precursor cells; especially mononuclear phagocytes; such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1; and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation; the regulation of bone resorption; and is required for normal bone and tooth development. Required for normal male and female fertility; and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton; regulates formation of membrane ruffles; cell adhesion and cell migration; and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1; PLCG2; GRB2; SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5- trisphosphate; that then lead to the activation of protein kinase C family members; especially PRKCD. Phosphorylation of PIK3R1; the regulatory subunit of phosphatidylinositol 3-kinase; leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1; and of the SRC family kinases SRC; FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain; or via adapter proteins; such as GRB2. Promotes activation of STAT family members STAT3; STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases; such as INPP5D/SHIP-1; that dephosphorylate the receptor and its downstream effectors; and by rapid internalization of the activated receptor.
- Host:
- Mouse
- Immunogen:
- This CSF1R antibody is generated from a mouse immunized with a recombinant protein.
- Isotyp:
- IgG1; k
- Molekulargewicht:
- 108 kDa
- Aufreinigung:
- This antibody is purified through a protein G column; followed by dialysis against PBS.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php