FHIT Antibody
Produktgrößen
400ul
£630,00
OAAB18687-400UL
Über dieses Produkt
- SKU:
- OAAB18687
- Zusätzliche Namen:
- FRA3B; AP3Aase
- translate.label.attr.clone:
- 1093CT23.1.2
- Klonalität:
- Monoclonal
- Weitere Details:
- Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A); but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival; such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds; but does not require its catalytic activity; it may in part come from the mitochondrial form; which sensitizes the low- affinity Ca(2+) transporters; enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
- Host:
- Mouse
- Immunogen:
- This FHIT antibody is generated from a mouse immunized with a recombinant protein.
- Isotyp:
- IgG1; k
- Molekulargewicht:
- 17 kDa
- Aufreinigung:
- This antibody is purified through a protein G column; followed by dialysis against PBS.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php