DAPK3 Antibody
Produktgrößen
100ul
£597,00
OAAB18357-100UL
Über dieses Produkt
- SKU:
- OAAB18357
- Zusätzliche Namen:
- DLK; ZIP; ZIPK
- Klonalität:
- Polyclonal
- Weitere Details:
- Serine/threonine kinase which is involved in the regulation of apoptosis; autophagy; transcription; translation; actin cytoskeleton reorganization; cell motility; smooth muscle contraction; and mitosis; particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal; depending on the cellular setting. The former is caspase- dependent; while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non- muscle cells. In smooth muscle; regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB); one of many subnuclear domains in the eukaryotic cell nucleus; and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome; its association with the GAIT complex and its subsequent involvement in transcript- selective translation inhibition.
- Host:
- Rabbit
- Isotyp:
- Rabbit Ig
- Molekulargewicht:
- 53 kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php