GABBR1 Antibody
Produktgrößen
100ul
£597,00
OAAB18315-100UL
Über dieses Produkt
- SKU:
- OAAB18315
- Zusätzliche Namen:
- GB1; GPRC3A; GABABR1; GABBR1-3
- Klonalität:
- Polyclonal
- Weitere Details:
- Component of a heterodimeric G-protein coupled receptor for GABA; formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor; only GABBR1 seems to bind agonists; while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors; such as adenylate cyclase. Signaling inhibits adenylate cyclase; stimulates phospholipase A2; activates potassium channels; inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels; whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation; slow wave sleep; muscle relaxation and antinociception. Activated by (-)-baclofen; cgp27492 and blocked by phaclofen.
- Host:
- Rabbit
- Isotyp:
- Rabbit Ig
- Molekulargewicht:
- 108 kDa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php