CDK5 Antibody
Produktgrößen
400ul
£630,00
OAAB17786-400UL
Über dieses Produkt
- SKU:
- OAAB17786
- Zusätzliche Namen:
- LIS7; PSSALRE
- Klonalität:
- Monoclonal
- Weitere Details:
- Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC; NOS3; VIM/vimentin; p35/CDK5R1; MEF2A; SIPA1L1; SH3GLB1; PXN; PAK1; MCAM/MUC18; SEPT5; SYN1; DNM1; AMPH; SYNJ1; CDK16; RAC1; RHOA; CDC42; TONEBP/NFAT5; MAPT/TAU; MAP1B; histone H1; p53/TP53; HDAC1; APEX1; PTK2/FAK1; huntingtin/HTT; ATM; MAP2; NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival; migration and differentiation; axonal and neurite growth; synaptogenesis; oligodendrocyte differentiation; synaptic plasticity and neurotransmission; by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39); especially in post-mitotic neurons; and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1; RAC1; RHOA; CDC42) or microtubule-binding proteins (e.g. MAPT/TAU; MAP2; MAP1B); and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18; SEPT5; SYN1; and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1; AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system ( CNS) ; regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis; vesicles fusion with the presynaptic membrane; and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3; and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation; and induces transactivation of p53/TP53 target genes; thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage; p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway; which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner; the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin; thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation; resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.
- Host:
- Mouse
- Immunogen:
- This antibody is generated from a mouse immunized with a recombinant protein from human.
- Isotyp:
- IgG1; kappa
- Molekulargewicht:
- 33 kDa
- Aufreinigung:
- This antibody is purified through a protein G column; followed by dialysis against PBS.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php