ATG7 Antibody - C-terminal region
Produktgrößen
400ul
£615,00
OAAB13623-400UL
Über dieses Produkt
- SKU:
- OAAB13623
- Zusätzliche Namen:
- GSA7; APG7L; APG7-LIKE
- Klonalität:
- Polyclonal
- Konzentration:
- 0.25 mg/ml
- Weitere Details:
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells; it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure; which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.
- Host:
- Rabbit
- Immunogen:
- This ATG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7.
- Isotyp:
- Ig
- Molekulargewicht:
- 78 kDa
- Proteindetails:
- Ubiquitin-like modifier-activating enzyme ATG7
- Aufreinigung:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php