DKK2 Antibody - N-terminal region
Produktgrößen
400ul
£615,00
OAAB11355-400UL
Über dieses Produkt
- SKU:
- OAAB11355
- Zusätzliche Namen:
- DKK-2
- Klonalität:
- Polyclonal
- Weitere Details:
- The 259-amino acid DKK2 protein; like DKK1; DKK3; and DKK4; possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains; which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1; DKK2; and DKK4; whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart; brain; skeletal muscle; and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.
- Host:
- Rabbit
- Immunogen:
- This DKK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-62 amino acids from the N-terminal region of human DKK2.
- Isotyp:
- Ig
- Molekulargewicht:
- 28447 Da
- Proteindetails:
- Dickkopf-related protein 2
- Aufreinigung:
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php