GNAS Antibody - C-terminal region
Produktgrößen
400ul
£597,00
OAAB09358-400UL
Über dieses Produkt
- SKU:
- OAAB09358
- Zusätzliche Namen:
- GNAS
- Klonalität:
- Polyclonal
- Konzentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Weitere Details:
- Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed; which results in different forms of the stimulatory G protein alpha subunit; a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene; but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a; pseudohypoparathyroidism type 1b; Albright hereditary osteodystrophy; pseudopseudohypoparathyroidism; McCune-Albright syndrome; progressive osseus heteroplasia; polyostotic fibrous dysplasia of bone; and some pituitary tumors.
- Host:
- Rabbit
- Immunogen:
- This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS.
- Isotyp:
- Rabbit IgG
- Molekulargewicht:
- 44 kDa
- Proteindetails:
- GNAS complex locus EMBL AAH89157.2
- Aufreinigung:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php