C9orf72 Antibody - C-terminal region
Produktgrößen
400ul
£630,00
OAAB09214-400UL
Über dieses Produkt
- SKU:
- OAAB09214
- Zusätzliche Namen:
- ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Component of the C9orf72-SMCR8 complex; a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex; C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP; converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form; thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. Plays a role in endosomal trafficking. May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6; leading to ARF6 inactivation. This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin; leading to cofilin activation. Positively regulates axon extension and axon growth cone size in spinal motor neurons. Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity
- Host:
- Rabbit
- Immunogen:
- This C9orf72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the C-terminal region of human C9orf72.
- Isotyp:
- Ig
- Molekulargewicht:
- 54 kDa
- Proteindetails:
- Uncharacterized protein C9orf72
- Aufreinigung:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php