DIO3 Antibody - C-terminal region
Produktgrößen
400ul
£597,00
OAAB06126-400UL
Über dieses Produkt
- SKU:
- OAAB06126
- Zusätzliche Namen:
- D3; 5DIII; TXDI3; DIOIII
- Klonalität:
- Polyclonal
- Konzentration:
- 0.45 mg/ml
- Weitere Details:
- DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3;3';5-triiodothyronine (T3) to inactive metabolites; 3;3';5'-triiodothyronine (RT3) and 3;3'-diiodothyronine (T2); respectively. This enzyme is highly expressed in the pregnant uterus; placenta; fetal and neonatal tissues; suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue; which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon; which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure; the sec insertion sequence (SECIS); which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
- Host:
- Rabbit
- Immunogen:
- This DIO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3.
- Isotyp:
- Rabbit Ig
- Molekulargewicht:
- 34 kDa
- Aufreinigung:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php