CD163 Antibody - N-terminal region
Produktgrößen
400ul
£597,00
OAAB04323-400UL
Über dieses Produkt
- SKU:
- OAAB04323
- Zusätzliche Namen:
- M130; MM130; SCARI1
- Klonalität:
- Polyclonal
- Konzentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Weitere Details:
- CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron; via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization; inositol triphosphate production and secretion of IL6 and CSF1.
- Host:
- Rabbit
- Immunogen:
- This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.
- Isotyp:
- Ig
- Molekulargewicht:
- 125451 Da
- Proteindetails:
- Scavenger receptor cysteine-rich type 1 protein M130
- Aufreinigung:
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php