GP6 Antibody - C-terminal region
Produktgrößen
400ul
£597,00
OAAB03099-400UL
Über dieses Produkt
- SKU:
- OAAB03099
- Zusätzliche Namen:
- GPIV; GPVI; BDPLT11
- Klonalität:
- Polyclonal
- Konzentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Weitere Details:
- Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining; exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix; with collagen types I; III; and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion; recruitment of additional platelets; and aggregation. In physiologic conditions; the resulting platelet plug is the initial hemostatic event limiting blood loss. However; exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al.; 2000 [PubMed 10961879]).
- Host:
- Rabbit
- Immunogen:
- This GP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6.
- Isotyp:
- Rabbit Ig
- Molekulargewicht:
- 36866 Da
- Proteindetails:
- Platelet glycoprotein VI
- Aufreinigung:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php