CHRNA7
Produktgrößen
25ul
£177,00
AVARP13018-T100-25UL
100 ul
£373,00
AVARP13018-T100-100UL
Über dieses Produkt
- SKU:
- AVARP13018-T100
- Zusätzliche Namen:
- NACHRA7; CHRNA7-2
- Klonalität:
- Polyclonal
- Konzentration:
- 1.0 mg/ml
- Weitere Details:
- The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains; a variable cytoplasmic loop; a fourth conserved transmembrane domain; and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel; displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by; and highly sensitive to; alpha-bungarotoxin. Once this receptor binds acetylcholine; it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.
- Gendetails:
- Cholinergic receptor; nicotinic; alpha 7 (neuronal)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA7
- Molekulargewicht:
- 56 kDa
- Proteindetails:
- Neuronal acetylcholine receptor subunit alpha-7
- Aufreinigung:
- Protein A purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php