Eif4g2 Antibody-N-terminal region
Produktgrößen
25ul
£177,00
ARP90937-P050-25UL
100 ul
£412,00
ARP90937-P050-100UL
Über dieses Produkt
- SKU:
- ARP90937-P050
- Zusätzliche Namen:
- Na; DAP; Nat; p97; Nat1; DAP-5; Natm1; E130105L11Rik
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F); which is a cap binding protein complex that consists of three subunits: eIF4A; eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G; that contains the binding sites for eIF4A and eIF3; eIF4G in addition; contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation; this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA; which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene.
- Gendetails:
- eukaryotic translation initiation factor 4; gamma 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of mouse EIF4G2
- Molekulargewicht:
- 99 kDa
- Proteindetails:
- eukaryotic translation initiation factor 4 gamma 2
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php