Ddx58 Antibody Middle region
Produktgrößen
25ul
£177,00
ARP89580-P050-25UL
100 ul
£412,00
ARP89580-P050-100UL
Über dieses Produkt
- SKU:
- ARP89580-P050
- Zusätzliche Namen:
- RI; RIG-I; RLR-1; C330021E21; 6430573D20Rik
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety; blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes; including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: newcastle disease virus (NDV) and Sendai virus (SeV); Rhabdoviridae: vesicular stomatitis virus (VSV); Orthomyxoviridae: influenza A and B virus; Flaviviridae: Japanese encephalitis virus (JEV); hepatitis C virus (HCV); dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and orthoreovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III; such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation; bacterial phagocytosis and in the regulation of cell migration.
- Gendetails:
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of mouse DDX58
- Molekulargewicht:
- 51 kDa
- Proteindetails:
- probable ATP-dependent RNA helicase DDX58
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php