Atf4 Antibody Middle region
Produktgrößen
25ul
£177,00
ARP89000-P050-25UL
100 ul
£412,00
ARP89000-P050-100UL
Über dieses Produkt
- SKU:
- ARP89000-P050
- Zusätzliche Namen:
- Atf-; C/AT; CREB; Atf-4; C/ATF; CREB2; CREB-2; TAXREB; TAXREB67
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'); a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP; activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
- Gendetails:
- activating transcription factor 4
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle terminal region of mouse ATF4
- Molekulargewicht:
- 38 kDa
- Proteindetails:
- cyclic AMP-dependent transcription factor ATF-4
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php