Cdk4 Antibody Middle region
Produktgrößen
25ul
£177,00
ARP88863-P050-25UL
100 ul
£412,00
ARP88863-P050-100UL
Über dieses Produkt
- SKU:
- ARP88863-P050
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1Â phase. Hypophosphorylates RB1 in early G1Â phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex; cyclin D/CDK4/CDKN1B; required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
- Gendetails:
- cyclin-dependent kinase 4
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of rat CDK4
- Molekulargewicht:
- 33 kDa
- Proteindetails:
- Cyclin-dependent kinase 4
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php