DDB1 Antibody - middle region
Produktgrößen
25ul
£177,00
ARP87409-P050-25UL
100 ul
£412,00
ARP87409-P050-100UL
Über dieses Produkt
- SKU:
- ARP87409-P050
- Zusätzliche Namen:
- XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However; it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition; Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q; but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
- Gendetails:
- damage specific DNA binding protein 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle terminal region of Human DDB1
- Molekulargewicht:
- 125 kDa
- Proteindetails:
- DNA damage-binding protein 1
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php