DCTN1 Antibody - middle region
Produktgrößen
25ul
£177,00
ARP81499-P050-25UL
100 ul
£412,00
ARP81499-P050-100UL
Über dieses Produkt
- SKU:
- ARP81499-P050
- Zusätzliche Namen:
- P135; DP-150; DAP-150
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- This gene encodes the largest subunit of dynactin; a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions; including ER-to-Golgi transport; the centripetal movement of lysosomes and endosomes; spindle formation; chromosome movement; nuclear positioning; and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
- Gendetails:
- dynactin subunit 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human DCTN1
- Molekulargewicht:
- 140 kDa
- Proteindetails:
- dynactin subunit 1
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php