ATXN1 Antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP79177-P050-25UL
100 ul
£412,00
ARP79177-P050-100UL
Über dieses Produkt
- SKU:
- ARP79177-P050
- Zusätzliche Namen:
- ATX1; SCA1; D6S504E
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum; brain stem and spinal cord. Clinically; ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous; with five genetic loci; designated spinocerebellar ataxia (SCA) 1; 2; 3; 4 and 6; being assigned to five different chromosomes. ADCAII; which always presents with retinal degeneration (SCA7); and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5); are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats; producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable; usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6; and it has been determined that the diseased allele contains 41-81 CAG repeats; compared to 6-39 in the normal allele; and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.
- Gendetails:
- ataxin 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human ATXN1
- Molekulargewicht:
- 87 kDa
- Proteindetails:
- ataxin-1
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php