CHCHD2 Antibody - middle region
Produktgrößen
25ul
£177,00
ARP79161-P050-25UL
100 ul
£412,00
ARP79161-P050-100UL
Über dieses Produkt
- SKU:
- ARP79161-P050
- Zusätzliche Namen:
- MNRR1; NS2TP; MIX17B; PARK22; C7orf17
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress; the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2; a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J; binding of this protein activates the oxygen responsive element at four percent oxygen. In addition; it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli; mitochondrial levels of this protein decrease; allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.
- Gendetails:
- coiled-coil-helix-coiled-coil-helix domain containing 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human CHCHD2
- Molekulargewicht:
- 16 kDa
- Proteindetails:
- coiled-coil-helix-coiled-coil-helix domain-containing protein 2
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php