DIO3 Antibody - middle region
Produktgrößen
25ul
£177,00
ARP78159-P050-25UL
100 ul
£412,00
ARP78159-P050-100UL
Über dieses Produkt
- SKU:
- ARP78159-P050
- Zusätzliche Namen:
- D3; 5DIII; TXDI3; DIOIII
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3;3';5-triiodothyronine (T3) to inactive metabolites; 3;3';5'-triiodothyronine (RT3) and 3;3'-diiodothyronine (T2); respectively. This enzyme is highly expressed in the pregnant uterus; placenta; fetal and neonatal tissues; suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue; which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon; which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure; the sec insertion sequence (SECIS); which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
- Gendetails:
- deiodinase; iodothyronine; type III
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human DIO3
- Molekulargewicht:
- 34 kDa
- Proteindetails:
- thyroxine 5-deiodinase
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php