BRSK2 Antibody - middle region
Produktgrößen
25ul
£177,00
ARP73774-P050-25UL
100 ul
£412,00
ARP73774-P050-100UL
Über dieses Produkt
- SKU:
- ARP73774-P050
- Zusätzliche Namen:
- SAD1; SADA; STK29; PEN11B; C11orf7
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- BRSK2 is a serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis; cell cycle progress and insulin secretion. It phosphorylates CDK16; CDC25C; MAPT/TAU; PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1; acts as a key regulator of polarization of cortical neurons; probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. It also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons; leading to down-regulate WEE1 activity in polarized neurons. It plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. It plays a role in the regulation of insulin secretion in response to elevated glucose levels; probably via phosphorylation of CDK16 and PAK1. While BRSK2 is phosphorylated at Thr-174 can inhibit insulin secretion; BRSK2 is phosphorylated at Thr-260 can promote insulin secretion. It regulates reorganization of the actin cytoskeleton. It may play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of Human BRSK2
- Molekulargewicht:
- 84kDa
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php