Apbb1 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP55471-P050-25UL
100 ul
£412,00
ARP55471-P050-100UL
Über dieses Produkt
- SKU:
- ARP55471-P050
- Zusätzliche Namen:
- Rir; Fe65
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs); recruiting other pro-apoptosis factors such as MAPK8/JNK1. Apbb1 is required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60; probably explains its trancription activation activity.Apbb1 functions in association with TSHZ3; SET and HDAC factors as a transcriptional repressor; that inhibits the expression of CASP4. Apbb1 is associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
- Gendetails:
- Amyloid beta (A4) precursor protein-binding; family B; member 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Molekulargewicht:
- 78kDa
- Proteindetails:
- Amyloid beta A4 precursor protein-binding family B member 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php