GUCA1A antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP54309-P050-25UL
100 ul
£412,00
ARP54309-P050-100UL
Über dieses Produkt
- SKU:
- ARP54309-P050
- Zusätzliche Namen:
- COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase; the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and; presumably; increased cell death. This gene is expressed in retina and spermatagonia.
- Gendetails:
- Guanylate cyclase activator 1A (retina)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
- Molekulargewicht:
- 23kDa
- Proteindetails:
- Guanylyl cyclase-activating protein 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php