ADC antibody - middle region
Produktgrößen
25ul
£177,00
ARP52476-P050-25UL
100 ul
£412,00
ARP52476-P050-100UL
Über dieses Produkt
- SKU:
- ARP52476-P050
- Zusätzliche Namen:
- ADC; AZI2; ODCp; AZIB1; ODC-p; ODC1L
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- The protein encoded by this gene belongs to the antizyme inhibitor family; which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC; the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however; retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation; as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2; the second member of this gene family. Like antizyme inhibitor 1; antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However; unlike antizyme inhibitor 1; which is ubiquitously expressed and localized in the nucleus and cytoplasm; antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries; adrenal glands and pancreas; and in mast cells. The exact function of this gene is not known; however; available data suggest its role in cell growth; spermiogenesis; vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene; stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene.
- Gendetails:
- antizyme inhibitor 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human ADC
- Molekulargewicht:
- 50kDa
- Proteindetails:
- antizyme inhibitor 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php